What Is the Liver’s Role, How Does It Become toxic, and How Can I Keep Mine Healthy?

Liver is the largest solid internal organ. It performs more than 400 tasks to keep the body healthy. The most important are metabolism. The liver filters everything that is eaten or consumed, whether it is food, alcohol, medicine, or toxins. Food is digested by the stomach and intestine, absorbed into the blood, and then transported to the liver. The liver is clever. It knows when to detoxify, when to excrete toxins via urine or stool, when to store nutrients, and when to bring back them into the blood.

The human liver is an amazing organ. Every day, it produces bile, converts nutrients from your diet, removes toxins from your blood, breaks down fats, alcohol, and medications, regulates blood sugar and hormone levels, stores iron, and does a variety of other things.

What happens if the liver fails?

Liver failure can affect many of your body's organs. Acute liver failure can result in infections, electrolyte deficiencies, and bleeding. Without treatment, both acute and chronic liver failure can lead to death.

Do you know liver is the only organ that can regenerate itself after being damaged. Even after 90% of the liver has been removed, it can regrow to normal size. However, the liver is not invincible. Many diseases and exposures can damage it beyond repair

Factors that cause for Liver damage & Disease

v  Exposure to Toxins

v  Harmful supplements/Medications

v  Too Much Alcohol

v  Obesity, Diabetes or High Cholesterol                                              

v  An undiagnosed hepatitis infection


Immune-mediated hepatitis in humans: Autoimmune hepatitis occurs when the body's immune system, which ordinarily attacks viruses, bacteria, and other pathogens, instead targets the liver. This attack on your liver can cause chronic inflammation and significant liver cell damage.

How can I keep my liver healthy?

The body’s top performer deserves VIP treatment

v  Be careful about alcohol Consumption

v  Cleanse produce and avoid toxins

v  Get vaccinated against, Hepatitis A, B & C

v  Watch out for medications and herbs

v  Exercise and eat healthy

Dabur Research Foundation is providing services on different preclinical models on drug induced Liver Injury. DRF has well validated animal model for this indication. Polyherbal formulation, Novel formulations, Pharmaceuticals, Nutraceuticals etc. using below mentioned models for claim substantiation & proof of concept

*     Paracetamol induced hepatotoxicity in rats

*     Carbon Tetrachloride induced hepatotoxicity in rats

*     Ethanol Induced hepatotoxicity in rats

*     Concanavalin A-induced liver injury mouse model

*     LPS (Lipopolysaccharide) induced liver inflammation model


Comments

Post a Comment

Popular posts from this blog

Translational Research

  For the birth of something new, there has to be a happening. Newton saw an apple fall; James Watt watched a kettle boil; Roentgen fogged some photographic plates. And these people knew enough to translate ordinary happenings into something new - Alexander Fleming   Translation is to convert practical into practice. Translational research is the research process that investigates and translates nonclinical research results into clinical applications and tests their safety and efficacy in a Phase 1 clinical trial. It is aimed at translating (converting) results of basic research into results that directly benefit humans. Translational research involves the application of knowledge gained through basic research to studies that could support the development of new products. For example, translational research in the field of medicine may involve using knowledge of the biology of a disease to identify and evaluate chemical compounds in disease models, with a view to selecting potentia
Read more

Claim Substantiation

  Before I joined the industry, I always used to think “does the claim on my shampoo bottle or my body lotion really true or it is just a random statement”. My work made me believe that the words written on the label of cosmetic products are reliable and   backed by scientific data. Every claim on the label is always substantiated by studies. Claim  is a statement made in  advertising / marketing  about the benefits, characteristics, and/ or performance of a  product  or  service  designed to persuade the  customer  to make a purchase. Claim S ubstantiation is the process of proving and documenting that claim made about products are true. Claims should not be misleading and should allow the consumer to make an informative decision based on claims that are legally compliant, truthful, honest, fair and backed up with adequate evidence. Claims may relate to health (e.g. does not contain parabens, pesticides, heavy metals, etc.), or to performance (e.g. “this product reduces acne”,
Read more

Biomarkers

  “Your body will be around a lot more than an expensive handbag. Invest in yourself”- Anonymous Advanced technology has been a boon to human mankind but it has also proved to be a curse. Technology has led to changed lifestyle which in turn has caused the tremendous evolution of the chronic diseases and thus the burden on the human mankind. Worldwide, large population suffers from one or the other disease, thus, having unhealthy body. Wellness is a state of physical, emotional, sexual and cognitive health wherein the body is in a state of balance. It can be measured by estimating the expression levels of various biomarkers that are pre-requisite for a healthy lifestyle. Any offset of these biomarkers can lead to unhealthy state of the body. Biomarkers are defined as biological molecules which are found in body fluids such as blood, urine, CSF or tissues and are indicative of a normal or an abnormal process in the body. They are often used to predict well-being of the body and ho
Read more